Unknown

Dataset Information

0

1,2-Benzenedithiol and Toluene-3,4-dithiol Arsenic(III) Complexes-Synthesis, Structure, Spectroscopic Characterization and Toxicological Studies.

ABSTRACT: A new group of arsenic(III) complexes with bidentate S,S-donor ligands, 1,2-benzenedithiol (Ph(SH)2) and toluene-3,4-dithiol (MePh(SH)2), were synthesized. The use of arsenic(III) iodide and bromide promoted the formation of neutral complexes (1-4) with the general formula AsX(LS2) (X = I or Br, L = MePh or Ph). The crystal structures of these compounds were determined using single-crystal X-ray diffraction (scXRD). Unlike other arsenic(III) complexes, AsBr(PhS2) complex (2) was found to crystallize with a rare 13 molecules in the asymmetric unit. The compounds were also characterized by conventional physico-chemical techniques (Fourier transform infrared (FT-IR) spectroscopy, ultraviolet-visible (UV-Vis) spectroscopy, nuclear magnetic resonance (NMR), high-performance liquid chromatography (HPLC), elemental analysis (EA) and electrospray ionization-mass spectrometry (ESI-MS)). The results from structural and spectroscopic studies were supported by DFT calculations using the B3LYP/LANL2DZ and (or) 6-31+G(d,p) approaches. The cytotoxicity of these complexes was estimated for human acute promyelocytic leukemia cell line (NB4). They exhibited remarkable cytotoxicities after 48 h of treatment with IC50 equal to about 10 µM and 40 µM for complexes with 1,2-benzenedithiolato and toluene-3,4-dithiolato ligand, respectively. Their toxicity was lower than that of commonly used chemotherapeutic As2O3 (IC50 = 1.4 µM).

SUBMITTER: Lyczko M 

PROVIDER: S-EPMC6864545 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

1,2-Benzenedithiol and Toluene-3,4-dithiol Arsenic(III) Complexes-Synthesis, Structure, Spectroscopic Characterization and Toxicological Studies.

Lyczko Monika M   Lyczko Krzysztof K   Majkowska-Pilip Agnieszka A   Bilewicz Aleksander A  

Molecules (Basel, Switzerland) 20191026 21

A new group of arsenic(III) complexes with bidentate S,S-donor ligands, 1,2-benzenedithiol (Ph(SH)<sub>2</sub>) and toluene-3,4-dithiol (MePh(SH)<sub>2</sub>), were synthesized. The use of arsenic(III) iodide and bromide promoted the formation of neutral complexes (<b>1</b>-<b>4</b>) with the general formula AsX(LS<sub>2</sub>) (X = I or Br, L = MePh or Ph). The crystal structures of these compounds were determined using single-crystal X-ray diffraction (scXRD). Unlike other arsenic(III) complex  ...[more]

Similar Datasets

Unknown 1-Butyl-pyridinium bis-(1,2-dicyano-ethene-1,2-dithiol-ato)nickelate(III).
| S-EPMC3246985 | biostudies-literature
Unknown Spectroscopic and computational studies of (mu-oxo)(mu-1,2-peroxo)diiron(III) complexes of relevance to nonheme diiron oxygenase intermediates.
| S-EPMC2736334 | biostudies-literature
Unknown 3-Butyl-1-methyl-1H-imidazol-3-ium bis-(1,2-dicyano-ethene-1,2-dithiol-ato-?S,S')nickel(III).
| S-EPMC3238640 | biostudies-literature
Unknown 1-(4-Cyano-benz-yl)-3,5-dimethyl-pyridinium bis-(benzene-1,2-dithiol-ato)nickelate(III).
| S-EPMC3051972 | biostudies-literature
Unknown 1-(4-Iodo-benz-yl)-3-methyl-pyridinium bis-(benzene-1,2-dithiol-ato)nickelate(III).
| S-EPMC3247529 | biostudies-literature
Unknown Thermodynamic and Spectroscopic Studies of the Complexes Formed in Tartaric Acid and Lanthanide(III) Ions Binary Systems.
| S-EPMC7179146 | biostudies-literature
Unknown Fe(III) and Cu(II) Complexes of Chlorogenic Acid: Spectroscopic, Thermal, Anti-/Pro-Oxidant, and Cytotoxic Studies.
| S-EPMC9572621 | biostudies-literature
Unknown 1,2-Bis(1,3-dithiol-2-yl-idene)hydrazine.
| S-EPMC2961747 | biostudies-literature
Unknown 1-(3,4-Dichloro-benz-yl)pyridinium bis-(2-sulfanyl-idene-1,3-dithiole-4,5-dithiol-ato-κS,S')nickelate(III).
| S-EPMC3246987 | biostudies-literature
Unknown Spectroscopic studies of the anaerobic enzyme-substrate complex of catechol 1,2-dioxygenase.
| S-EPMC3418915 | biostudies-literature