Ontology highlight
ABSTRACT:
SUBMITTER: Gao T
PROVIDER: S-EPMC7804935 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Nature communications 20210112 1
Stably acquired mutations in hematopoietic cells represent substrates of selection that may lead to clonal hematopoiesis (CH), a common state in cancer patients that is associated with a heightened risk of leukemia development. Owing to technical and sample size limitations, most CH studies have characterized gene mutations or mosaic chromosomal alterations (mCAs) individually. Here we leverage peripheral blood sequencing data from 32,442 cancer patients to jointly characterize gene mutations (n ...[more]