Ontology highlight
ABSTRACT:
SUBMITTER: Dostal V
PROVIDER: S-EPMC7806247 | biostudies-literature | 2019 May
REPOSITORIES: biostudies-literature
Dostal Vishantie V Churchill Mair E A MEA
Biochimica et biophysica acta. Gene regulatory mechanisms 20190223 5
In eukaryotes, cytosine methylation of nuclear DNA at CpG sequences (<sup>5m</sup>CpG) regulates epigenetic inheritance through alterations in chromatin structure. However, mitochondria lack nucleosomal chromatin, therefore the molecular mechanisms by which <sup>5m</sup>CpG influences mitochondria must be different and are as yet unknown. Mitochondrial Transcription Factor A (TFAM) is both the primary DNA-compacting protein in the mitochondrial DNA (mtDNA) nucleoid and a transcription-initiation ...[more]