CD206+?macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model.
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ABSTRACT:
SUBMITTER: Ono Y
PROVIDER: S-EPMC7807007 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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CD206+ macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model.
Ono Yosuke Y Yoshino Osamu O Hiraoka Takehiro T Sato Erina E Furue Akiko A Nawaz Allah A Hatta Hideki H Fukushi Yoshiyuki Y Wada Shinichiro S Tobe Kazuyuki K Hirota Yasushi Y Osuga Yutaka Y Unno Nobuya N Saito Shigeru S
Scientific reports 20210113 1
In endometriosis, M2 MΦs are dominant in endometriotic lesions, but the actual role of M2 MΦ is unclear. CD206 positive (+) MΦ is classified in one of M2 type MΦs and are known to produce cytokines and chemokines. In the present study, we used CD206 diphtheria toxin receptor mice, which enable to deplete CD206+ cells with diphtheria toxin (DT) in an endometriosis mouse model. The depletion of CD206+ MΦ decreased the total weight of endometriotic-like lesions significantly (p < 0.05). In the endo ...[more]
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