Dataset Information

Kernel-based formulation of intervening opportunities for spatial interaction modelling.

ABSTRACT: Understanding spatial interactions such as human mobility has been one of the main analytical themes in geography, spatial economics, and traffic engineering for a long time. The intervening opportunities models, including the radiation model, provide a framework to elucidate spatial interactions generated by an individual's distance-ordered decision-making process. However, such classical definitions of intervening opportunities have often failed to predict realistic flow volumes, particularly for short-distance flows. To overcome this problem, we have proposed a new formulation of intervening opportunities with a kernel function to introduce a fuzziness in spatial search behaviours of destinations, to develop a new variant of the radiation model. The mobility patterns resulting from the modified radiation model that included kernel-based intervening opportunities outperformed the original radiation model when fitted to four datasets of inter-regional flows.

SUBMITTER: Kotsubo M

PROVIDER: S-EPMC7807028 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Kernel-based formulation of intervening opportunities for spatial interaction modelling.

Kotsubo Masaki M Nakaya Tomoki T

Scientific reports 20210113 1

Understanding spatial interactions such as human mobility has been one of the main analytical themes in geography, spatial economics, and traffic engineering for a long time. The intervening opportunities models, including the radiation model, provide a framework to elucidate spatial interactions generated by an individual's distance-ordered decision-making process. However, such classical definitions of intervening opportunities have often failed to predict realistic flow volumes, particularly ...[more]

PMID: 33441794

Similar Datasets

Project description:BackgroundStudies have shown that miRNAs are functionally associated with the development of many human diseases, but the roles of miRNAs in diseases and their underlying molecular mechanisms have not been fully understood. The research on miRNA-disease interaction has received more and more attention. Compared with the complexity and high cost of biological experiments, computational methods can rapidly and efficiently predict the potential miRNA-disease interaction and can be used as a beneficial supplement to experimental methods.ResultsIn this paper, we proposed a novel computational model of kernel neighborhood similarity and multi-network bidirectional propagation (KNMBP) for miRNA-disease interaction prediction, especially for new miRNAs and new diseases. First, we integrated multiple data sources of diseases and miRNAs, respectively, to construct a novel disease semantic similarity network and miRNA functional similarity network. Secondly, based on the modified miRNA-disease interactions, we use the kernel neighborhood similarity algorithm to calculate the disease kernel neighborhood similarity and the miRNA kernel neighborhood similarity. Finally, we utilize bidirectional propagation algorithm to predict the miRNA-disease interaction scores based on the integrated disease similarity network and miRNA similarity network. As a result, the AUC value of 5-fold cross validation for all interactions by KNMBP is 0.93126 based on the commonly used dataset, and the AUC values for all interactions, for all miRNAs, for all disease is 0.93795、0.86363、0.86937 based on another dataset extracted by ourselves, which are higher than other state-of-the-art methods. In addition, our model has good parameter robustness. The case study further demonstrated the predictive performance of the model for novel miRNA-disease interactions.ConclusionsOur KNMBP algorithm efficiently integrates multiple omics data from miRNAs and diseases to stably and efficiently predict potential miRNA-disease interactions. It is anticipated that KNMBP would be a useful tool in biomedical research.

Dataset Information

Kernel-based formulation of intervening opportunities for spatial interaction modelling.

Publications

Kernel-based formulation of intervening opportunities for spatial interaction modelling.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets