Dataset Information

Long-term remission and biologic persistence rates: 12-year real-world data.

ABSTRACT:

Background

Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains limited. This study explores predictors of remission and persistence of the initial biologic therapy in patients after 12?years. Furthermore, outcomes with adalimumab and etanercept are compared.

Patients and methods

RA and PsA patients were prospectively recruited from a biologic clinic. Outcomes on commencing therapy, at 1 year and 12?years were reviewed. Demographics, medications, morning stiffness, patient global health score, tender and swollen joint counts, antibody status, CRP and HAQ were collected. Outcomes at 1 year and 12?years are reported and predictors of biologic persistence and EULAR-defined remission (DAS28-CRP ResultsA total of 403 patients (274 RA and 129 PsA) were analysed. PsA patients were more likely to be male, in full-time employment and have completed higher education. PsA had higher remission rates than RA at both 1 year (60.3% versus 34.5%, p?ConclusionsThis is the first study to show better response to biologic therapy in PsA compared to RA at 12?years. Long-term persistence with initial biologic agent was high and was predicted by biologic persistence and low-disease activity at 1 year. Interestingly, PsA patients had higher levels of employment, educational attainment, and long-term remission rates compared to RA patients.

SUBMITTER: Murray K

PROVIDER: S-EPMC7807520 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Long-term remission and biologic persistence rates: 12-year real-world data.

Murray Kieran K Turk Matthew M Alammari Yousef Y Young Francis F Gallagher Phil P Saber Tajvur T Fearon Ursula U Veale Douglas J DJ

Arthritis research & therapy 20210113 1

<h4>Background</h4>Biologic therapies have greatly improved outcomes in rheumatoid arthritis (RA) and psoriatic arthritis (PsA). Yet, our ability to predict long-term remission and persistence or continuation of therapy remains limited. This study explores predictors of remission and persistence of the initial biologic therapy in patients after 12 years. Furthermore, outcomes with adalimumab and etanercept are compared.<h4>Patients and methods</h4>RA and PsA patients were prospectively recruited ...[more]

PMID: 33441191

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Dataset Information

Long-term remission and biologic persistence rates: 12-year real-world data.

Background

Patients and methods

Publications

Long-term remission and biologic persistence rates: 12-year real-world data.

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