Dataset Information

Multi-center evaluation of dose conformity in stereotactic body radiotherapy.

ABSTRACT:

Background and purpose

Stereotactic body radiotherapy (SBRT) is an emerging technique for treating oligometastases, but limited data is available on what plan quality is achievable for a range of modalities and clinical sites.

Methods

SBRT plans for lung, spine, bone, adrenal, liver and node sites from 17 participating centers were reviewed. Centers used various delivery techniques including static and rotational intensity-modulation and multiple non-coplanar beams. Plans were split into lung and other body sites and evaluated with different plan quality metrics, including two which are independent of target coverage; "prescription dose spillage" (PDS) and "modified gradient index" (MGI). These were compared to constraints from the ROSEL and RTOG 0813 clinical trials.

Results

Planning target volume (PTV) coverage was compromised (PTV V100%?3.

Conclusions

Updated guidance for lung and other body site SBRT plan quality using the PDS and MGI metrics is presented.

SUBMITTER: Lee J

PROVIDER: S-EPMC7807546 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Multi-center evaluation of dose conformity in stereotactic body radiotherapy.

Lee Jonny J Dean Christopher C Patel Rushil R Webster Gareth G Eaton David J DJ

Physics and imaging in radiation oncology 20190701

<h4>Background and purpose</h4>Stereotactic body radiotherapy (SBRT) is an emerging technique for treating oligometastases, but limited data is available on what plan quality is achievable for a range of modalities and clinical sites.<h4>Methods</h4>SBRT plans for lung, spine, bone, adrenal, liver and node sites from 17 participating centers were reviewed. Centers used various delivery techniques including static and rotational intensity-modulation and multiple non-coplanar beams. Plans were spl ...[more]

PMID: 33458276

Similar Datasets

Project description:Purpose and objectiveTo develop expert consensus statements on multiparametric dose prescriptions for stereotactic body radiotherapy (SBRT) aligning with ICRU report 91. These statements serve as a foundational step towards harmonizing current SBRT practices and refining dose prescription and documentation requirements for clinical trial designs.Materials and methodsBased on the results of a literature review by the working group, a two-tier Delphi consensus process was conducted among 24 physicians and physics experts from three European countries. The degree of consensus was predefined for overarching (OA) and organ-specific (OS) statements (≥ 80%, 60-79%, < 60% for high, intermediate, and poor consensus, respectively). Post-first round statements were refined in a live discussion for the second round of the Delphi process.ResultsExperts consented on a total of 14 OA and 17 OS statements regarding SBRT of primary and secondary lung, liver, pancreatic, adrenal, and kidney tumors regarding dose prescription, target coverage, and organ at risk dose limitations. Degree of consent was ≥ 80% in 79% and 41% of OA and OS statements, respectively, with higher consensus for lung compared to the upper abdomen. In round 2, the degree of consent was ≥ 80 to 100% for OA and 88% in OS statements. No consensus was reached for dose escalation to liver metastases after chemotherapy (47%) or single-fraction SBRT for kidney primaries (13%). In round 2, no statement had 60-79% consensus.ConclusionIn 29 of 31 statements a high consensus was achieved after a two-tier Delphi process and one statement (kidney) was clearly refused. The Delphi process was able to achieve a high degree of consensus for SBRT dose prescription. In summary, clear recommendations for both OA and OS could be defined. This contributes significantly to harmonization of SBRT practice and facilitates dose prescription and reporting in clinical trials investigating SBRT.

Dataset Information

Multi-center evaluation of dose conformity in stereotactic body radiotherapy.

Background and purpose

Methods

Results

Conclusions

Publications

Multi-center evaluation of dose conformity in stereotactic body radiotherapy.

Similar Datasets

OmicsDI is part of the ELIXIR infrastructure

Tweets