Post-transplant absolute lymphocyte count predicts early cytomegalovirus infection after heart transplantation.

ABSTRACT: Immunosuppressive therapy can decrease rejection episodes and increase the risk of severe and fatal infections in heart transplantation (HT) recipients. Immunosuppressive therapy can also decrease the absolute lymphocyte count (ALC), but the relationship between early post-transplant ALC and early cytomegalovirus (CMV) infection is largely unknown, especially in HT. We retrospectively analyzed 58 HT recipients who tested positive for CMV IgG antibody and received basiliximab induction therapy. We collected preoperative and 2-month postoperative data on ALC and CMV load. The CMV load?>?1200 IU/mL was used as the cutoff value to define early CMV infection. Post-transplant lymphopenia was defined as an ALC of?

SUBMITTER: Yoon M 

PROVIDER: S-EPMC7809401 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature