Ontology highlight
ABSTRACT:
SUBMITTER: You G
PROVIDER: S-EPMC7810375 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
You Gihoon G Lee Yangsoon Y Kang Yeon-Woo YW Park Han Wook HW Park Kyeongsu K Kim Hyekang H Kim Young-Min YM Kim Sora S Kim Ji-Hae JH Moon Dain D Chung Hyejin H Son Wonjun W Jung Ui-Jung UJ Park Eunyoung E Lee Shinai S Son Yong-Gyu YG Eom Jaehyun J Won Jonghwa J Park Yunji Y Jung Jaeho J Lee Seung-Woo SW
Science advances 20210115 3
Cancer immunotherapy with 4-1BB agonists has limited further clinical development because of dose-limiting toxicity. Here, we developed a bispecific antibody (bsAb; B7-H3×4-1BB), targeting human B7-H3 (hB7-H3) and mouse or human 4-1BB, to restrict the 4-1BB stimulation in tumors. B7-H3×m4-1BB elicited a 4-1BB-dependent antitumor response in hB7-H3-overexpressing tumor models without systemic toxicity. BsAb primarily targets CD8 T cells in the tumor and increases their proliferation and cytokine ...[more]