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Stratification of Stage III colon cancer may identify a patient group not requiring adjuvant chemotherapy.


ABSTRACT:

Purpose

Adjuvant chemotherapy for colon cancer with lymph node involvement (Stage III) has been the standard of care since the 1990s. Meanwhile, considerable evolvement of surgery combined with dedicated histopathological examinations may have led to stage migration. Furthermore, prognostic factors other than lymph node involvement have proven to affect overall survival. Thus, adjuvant chemotherapy in Stage III colon cancer should be reconsidered. The objective was to compare recurrence rates and survival in stage III colon cancer patients treated with or without adjuvant chemotherapy. Further, to assess the impact of extensive mesenterectomy, lymph node stage and vascular invasion on outcome.

Methods

Consecutive patients operated for Stage III colon carcinoma between 31 December 2005 and 31 December 2015 were identified in the pathological code register by matching colon (T67) and either adenocarcinoma (M81403) or mucinous adenocarcinoma (M84803), with lymph node (T08) and metastasis of adenocarcinoma (M81406 or M84806). Medical records of all identified patients were reviewed.

Results

Of 216 identified patients, 69 received no postoperative adjuvant chemotherapy (group NC), 69 insufficient adjuvant chemotherapy (FLV or?ConclusionThe findings imply that subgroups of Stage III colon cancer patients have good prognosis also without adjuvant chemotherapy. For definite conclusions about necessity of adjuvant chemotherapy, prospective trials are needed.

SUBMITTER: Malik YG 

PROVIDER: S-EPMC7810647 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Stratification of Stage III colon cancer may identify a patient group not requiring adjuvant chemotherapy.

Malik Yasir G YG   Lyckander Lars Gustav LG   Lindstrøm Jonas C JC   Vinge-Holmquist Olof O   Sheikh Ariba E AE   Schultz Johannes K JK   Ignjatovic Dejan D  

Journal of cancer research and clinical oncology 20200913 1


<h4>Purpose</h4>Adjuvant chemotherapy for colon cancer with lymph node involvement (Stage III) has been the standard of care since the 1990s. Meanwhile, considerable evolvement of surgery combined with dedicated histopathological examinations may have led to stage migration. Furthermore, prognostic factors other than lymph node involvement have proven to affect overall survival. Thus, adjuvant chemotherapy in Stage III colon cancer should be reconsidered. The objective was to compare recurrence  ...[more]

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