Ontology highlight
ABSTRACT:
SUBMITTER: Adom D
PROVIDER: S-EPMC7811191 | biostudies-literature | 2020 Oct
REPOSITORIES: biostudies-literature
Adom Djamilatou D Dillon Stacey R SR Yang Jinfeng J Liu Hao H Ramadan Abdulraouf A Kushekhar Kushi K Hund Samantha S Albright Amanda A Kirksey Maykala M Adeniyan Titilayo T Lewis Katherine E KE Evans Lawrence L Wu Rebecca R Levin Steven D SD Mudri Sherri S Yang Jing J Rickel Erika E Seaberg Michelle M Henderson Katherine K Gudgeon Chelsea J CJ Wolfson Martin F MF Swanson Ryan M RM Swiderek Kristine M KM Peng Stanford L SL Hippen Keli L KL Blazar Bruce R BR Paczesny Sophie S
Science translational medicine 20201001 564
Acute graft-versus-host disease (aGVHD) remains a major complication of allogeneic hematopoietic cell transplantation (HCT). CD146 and CCR5 are proteins that mark activated T helper 17 (Th17) cells. The Th17 cell phenotype is promoted by the interaction of the receptor ICOS on T cells with ICOS ligand (ICOSL) on dendritic cells (DCs). We performed multiparametric flow cytometry in a cohort of 156 HCT recipients and conducted experiments with aGVHD murine models to understand the role of ICOSL<su ...[more]