Unknown

Dataset Information

0

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus.


ABSTRACT: Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite causing severe disease in humans, our understanding of the host and viral determinants of CCHFV pathogenesis are limited. A major limitation in the investigation of CCHF has been the lack of suitable small animal models. Wild-type mice are resistant to clinical isolates of CCHFV and consequently, mice must be deficient in type I interferon responses to study the more severe aspects of CCHFV. We report here a mouse-adapted variant of CCHFV that recapitulates in adult, immunocompetent mice the severe CCHF observed in humans. This mouse-adapted variant of CCHFV significantly improves our ability to study host and viral determinants of CCHFV-induced disease in a highly tractable mouse model.

SUBMITTER: Hawman DW 

PROVIDER: S-EPMC7811403 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

altmetric image

Publications

Immunocompetent mouse model for Crimean-Congo hemorrhagic fever virus.

Hawman David W DW   Meade-White Kimberly K   Leventhal Shanna S   Feldmann Friederike F   Okumura Atsushi A   Smith Brian B   Scott Dana D   Feldmann Heinz H  

eLife 20210108


Crimean-Congo hemorrhagic fever (CCHF) is a severe tick-borne febrile illness with wide geographic distribution. CCHF is caused by infection with the Crimean-Congo hemorrhagic fever virus (CCHFV) and case fatality rates can be as high as 30%. Despite causing severe disease in humans, our understanding of the host and viral determinants of CCHFV pathogenesis are limited. A major limitation in the investigation of CCHF has been the lack of suitable small animal models. Wild-type mice are resistant  ...[more]

Similar Datasets

| S-EPMC6714788 | biostudies-literature
| S-EPMC5120814 | biostudies-literature
| S-EPMC6256378 | biostudies-literature
| S-EPMC5708233 | biostudies-literature
| S-EPMC10646030 | biostudies-literature
| S-EPMC3557898 | biostudies-literature
| S-EPMC1563879 | biostudies-literature
| S-EPMC3309668 | biostudies-literature
| S-EPMC2953203 | biostudies-literature
| S-EPMC3320408 | biostudies-literature