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Genetic Variants of the MIF Gene and Susceptibility of Rectal Cancer.

ABSTRACT:

Background

Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.

Patients and methods

This case-control study evaluated associations of genetic variants of the MIF gene and serum level of MIF with susceptibility of RC.

Results

We found MIF level was associated with an increased risk of RC (OR for per unit: 1.38, 95% CI:1.32-1.44; P?ConclusionThis study suggests that MIF plays an important role in the carcinogenesis of RC and could be used as a biomarker for early detection and prediction of RC.

SUBMITTER: Chuo D

PROVIDER: S-EPMC7812028 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Genetic Variants of the <i>MIF</i> Gene and Susceptibility of Rectal Cancer.

Chuo Dongyu D Lin Dapeng D Yin Mingdi M Chen Yuze Y

Pharmacogenomics and personalized medicine 20210112

<h4>Background</h4>Rectal cancer (RC) has been documented to be a highly invasive malignant neoplasm worldwide. Macrophage migration inhibitory factor (MIF) is a multifunctional cytokine involved in cell-mediated immunity, immunoregulation, inflammation. In vitro and in vivo studies have identified that MIF was involved in the carcinogenesis and progression of RC.<h4>Patients and methods</h4>This case-control study evaluated associations of genetic variants of the MIF gene and serum level of MIF ...[more]

PMID: 33469341

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