HDAC2 promotes the EMT of colorectal cancer cells and via the modular scaffold function of ENSG00000274093.1.
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ABSTRACT:
SUBMITTER: Qi ZP
PROVIDER: S-EPMC7812252 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
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HDAC2 promotes the EMT of colorectal cancer cells and via the modular scaffold function of ENSG00000274093.1.
Qi Zhi-Peng ZP Yalikong Ayimukedisi A Zhang Jia-Wei JW Cai Shi-Lun SL Li Bing B Di Sun S Lv Zhen-Tao ZT Xu En-Pan EP Zhong Yun-Shi YS Zhou Ping-Hong PH
Journal of cellular and molecular medicine 20201215 2
Histone deacetylase 2 (HDAC2), a member of the Histone deacetylase family, plays a vital role in various carcinomas. In this study, we identified that HDAC2 expression levels are associated with liver metastasis, higher T stages and poor prognosis in colorectal cancer. HDAC2 down-regulation via lentivirus-mediated expression of HDAC2-targeting shRNA reduced the in vitro migration and invasion ability of HCT116 cell as well as their liver metastasis in nude mouse xenografts. Mechanistically, HDAC ...[more]
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