Ontology highlight
ABSTRACT:
SUBMITTER: Mullani N
PROVIDER: S-EPMC7812316 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Mullani Nowsheen N Porozhan Yevheniia Y Mangelinck Adèle A Rachez Christophe C Costallat Mickael M Batsché Eric E Goodhardt Michele M Cenci Giovanni G Mann Carl C Muchardt Christian C
Life science alliance 20210114 3
Accumulation of senescent cells is an important contributor to chronic inflammation upon aging. The inflammatory phenotype of senescent cells was previously shown to be driven by cytoplasmic DNA. Here, we propose that cytoplasmic double-stranded RNA has a similar effect. We find that several cell types driven into senescence by different routes share an accumulation of long promoter RNAs and 3' gene extensions rich in retrotransposon sequences. Accordingly, these cells display increased expressi ...[more]