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Risk Factors for Mortality, Intensive Care Unit Admission, and Bacteremia in Patients Suspected of Sepsis at the Emergency Department: A Prospective Cohort Study.


ABSTRACT:

Background

There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department.

Methods

A prospective observational cohort study including 1690 patients was performed. Two multivariable logistic regression models were used to identify independent risk factors.

Results

Sequential organ failure assessment (SOFA) score of ≥2 and serum lactate of ≥2mmol/L were associated with all outcomes. Other independent risk factors were individual SOFA variables and systemic inflammatory response syndrome variables but varied per outcome. Mean arterial pressure <70 mmHg negatively impacted all outcomes.

Conclusions

These readily available measurements can help with early risk stratification and prediction of prognosis.

SUBMITTER: D'Onofrio V 

PROVIDER: S-EPMC7813192 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Risk Factors for Mortality, Intensive Care Unit Admission, and Bacteremia in Patients Suspected of Sepsis at the Emergency Department: A Prospective Cohort Study.

D'Onofrio Valentino V   D'Onofrio Valentino V   Meersman Agnes A   Vijgen Sara S   Cartuyvels Reinoud R   Messiaen Peter P   Gyssens Inge C IC  

Open forum infectious diseases 20201228 1


<h4>Background</h4>There is a clear need for a better assessment of independent risk factors for in-hospital mortality, intensive care unit admission, and bacteremia in patients presenting with suspected sepsis at the emergency department.<h4>Methods</h4>A prospective observational cohort study including 1690 patients was performed. Two multivariable logistic regression models were used to identify independent risk factors.<h4>Results</h4>Sequential organ failure assessment (SOFA) score of ≥2 an  ...[more]

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