Ontology highlight
ABSTRACT:
SUBMITTER: Wieclaw MM
PROVIDER: S-EPMC7814180 | biostudies-literature | 2021
REPOSITORIES: biostudies-literature
Więcław Michał Mateusz MM Furman Bartłomiej B
Beilstein journal of organic chemistry 20210113
Herein we present the direct asymmetric synthesis of tetrazole-functionalized 1-deoxynojirimycin derivatives from simple sugars via a Schwartz's reagent-mediated reductive amide functionalization followed by a variant of the Ugi-azide multicomponent reaction. The anomeric configurations of two products were unambiguously confirmed by X-ray analysis. This work also describes examples of interesting further transformations of the title products. Finally, some surprising observations regarding the ...[more]