Ontology highlight
ABSTRACT:
SUBMITTER: Zhang F
PROVIDER: S-EPMC7815836 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Zhang Fayun F Zheng Zifeng Z Barman Apurba Kumar AK Wang Zihao Z Wang Luyao L Zeng Wenfeng W Wang Luoyang L Qin Yan Y Pandey Asmita A Zhang Chunling C Liang Wei W
Communications biology 20210119 1
A major obstacle to immunotherapy is insufficient infiltration of effector immune cells into the tumor microenvironment. Radiotherapy greatly reduces tumor burden but relapses often occur. Here we show that the immunosuppressive tumor microenvironment was gradually established by recruiting Tregs after radiation. Despite tumors being controlled after depletion of Tregs in the irradiated area, improvement of mice survival remained poor. A much better antitumor effect was achieved with vaccination ...[more]