Ontology highlight
ABSTRACT:
SUBMITTER: Kim H
PROVIDER: S-EPMC7815936 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kim Hyunkee H Selvaraj Sridhar S Kiley James J Azzag Karim K Garay Bayardo I BI Perlingeiro Rita C R RCR
Stem cell reports 20201203 1
Inducible expression of PAX7 in differentiating pluripotent stem cells (PSCs) allows massively scalable generation of human myogenic progenitors, which upon transplantation into dystrophic muscles give rise to donor-derived myofibers and satellite cells. Therefore, PSC-derived PAX7<sup>+</sup> myogenic progenitors represent an attractive therapeutic approach to promote muscle regeneration. Work to date has used lentiviral vectors (LVs) that randomly integrate inducible PAX7 transgenes. Here, we ...[more]