Ontology highlight
ABSTRACT:
SUBMITTER: Wang Q
PROVIDER: S-EPMC7815944 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Wang Qinying Q Dong Xiaoxu X Hu Tingting T Qu Chao C Lu Jing J Zhou Yue Y Li Jinsong J Pei Gang G
Stem cell reports 20201223 1
Serotonin receptor 6 (5-HT<sub>6</sub>R), a typical G protein-coupled receptor (GPCR) mainly expressed in the neurogenic area with constitutive activity, is of particular interest as a promising target for emotional impairment. Here, we found that 5-HT<sub>6</sub>R was highly expressed in human NSCs and activation of the receptor promoted self-renewal of human NSCs, and thus induced the expansion and folding of human cerebral organoids; dysfunction of receptor or inhibition of its constitutive a ...[more]