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Correlation between Lsp1 (Rs3817198) and Casc (Rs4784227) Polymorphisms and the Susceptibility to Breast Cancer.


ABSTRACT:

Background

Breast cancer is classified as one of the common cancers among women worldwide. Within numerous genetic factors involved in the development of breast cancer, lsp1 and casc genes are both located on breast cancer susceptibility locus. While the SNP rs3817198 in lsp1 gene has a twilight association with breast cancer in different populations, casc rs4784227 polymorphisms have been reported to associate with breast tumor appearance in Asian, European, and African ancestry populations. The present report was designed a case-control group aimed at assessing the association of these two SNPs with breast cancer risk in the Iranian population.

Methods

In the case-control study of rs3817198 and rs4784227 polymorphisms in 100 women with breast cancer and 100 healthy women were examined by Tetra Arms PCR. Data collected using SPSS software and chi-square test and correlation coefficient were used for statistical analysis.

Results

The results of current study showed that the Chi-square of lsp1 rs3817198 and casc rs4784227 polymorphism genotypes in breast cancer, were reported to be 51.613 and 47.920, respectively. Also there has been a significance level of both polymorphisms resulting in the frequency of genotypes in these two polymorphisms between case and control group.

Conclusion

Our finding thus suggested that in both polymorphisms, homozygote genotype showed strong correlation with cancer susceptibility. While, TT genotype in lsp1 rs3817198 showed significant association with pathogenic properties, in the case of casc rs4784227 genotypes CC, and in second place, TT showed similar correlation.

SUBMITTER: Nourolahzadeh Z 

PROVIDER: S-EPMC7816788 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature

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Publications

Correlation between <i>Lsp1 (Rs3817198)</i> and <i>Casc (Rs4784227)</i> Polymorphisms and the Susceptibility to Breast Cancer.

Nourolahzadeh Zahra Z   Houshmand Massoud M   Mohammad Fawzia Mostafa FM   Ghorbian Saeed S  

Reports of biochemistry & molecular biology 20201001 3


<h4>Background</h4>Breast cancer is classified as one of the common cancers among women worldwide. Within numerous genetic factors involved in the development of breast cancer, <i>lsp1</i> and <i>casc</i> genes are both located on breast cancer susceptibility locus. While the SNP <i>rs3817198</i> in <i>lsp1</i> gene has a twilight association with breast cancer in different populations, <i>casc rs4784227</i> polymorphisms have been reported to associate with breast tumor appearance in Asian, Eur  ...[more]

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