Dataset Information

Early Chronic Kidney Disease Care Programme delays kidney function deterioration in patients with stage I-IIIa chronic kidney disease: an observational cohort study in Taiwan.

ABSTRACT:

Objectives

To investigate the effect of the Early Chronic Kidney Disease (CKD) Care Programme on CKD progression in patients with CKD stage I-IIIa.

Design

Observational cohort study.

Setting

Taipei Medical University Research Database from three affiliated hospitals.

Participants

Adult non-pregnant patients with CKD stage I-IIIa from Taipei Medical University Research Database between 1 January 2012 and 31 August 2017 were recruited. These patients were divided into Early CKD Care Programme participants (case) and non-participants (control). The models were matched by age, sex, estimated glomerular filtration rate and CKD stage with 1:2 propensity score to reduce bias between two groups.

Outcome measures

The risks of CKD stage I-IIIa progression to IIIb between Early CKD Care Programme participants and non-participants.

Results

Compared with the control group, the case group demonstrated more comorbidities and higher proportions of hypertension, diabetes mellitus, gout, dyslipidaemia, heart disease and cerebrovascular disease, but had lower risk of progression to CKD stage IIIb before and (HR 0.72; 95% CI 0.61 to 0.85) and after (adjusted HR (aHR) 0.67; 95% CI 0.55 to 0.81) adjustments. Moreover, Kaplan-Meier analysis revealed the cumulative incidence of CKD stage IIIb was significantly lower in the case group than in the control group. Finally, the programme was an independent protective factor against progression to stage IIIb, especially in patients with CKD stage IIIa before (HR 0.72; 95% CI 0.61 to 0.85) and after (aHR 0.67; 95% CI 0.55 to 0.81) adjustments.

Conclusions

The Early CKD Care Programme is an independent protective factor against progression of early CKD.

SUBMITTER: Niu SF

PROVIDER: S-EPMC7817788 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

ACCESS DATA

Publications

Early Chronic Kidney Disease Care Programme delays kidney function deterioration in patients with stage I-IIIa chronic kidney disease: an observational cohort study in Taiwan.

Niu Shu-Fen SF Wu Chung-Kuan CK Chuang Nai-Chen NC Yang Ya-Bei YB Chang Tzu-Hao TH

BMJ open 20210119 1

<h4>Objectives</h4>To investigate the effect of the Early Chronic Kidney Disease (CKD) Care Programme on CKD progression in patients with CKD stage I-IIIa.<h4>Design</h4>Observational cohort study.<h4>Setting</h4>Taipei Medical University Research Database from three affiliated hospitals.<h4>Participants</h4>Adult non-pregnant patients with CKD stage I-IIIa from Taipei Medical University Research Database between 1 January 2012 and 31 August 2017 were recruited. These patients were divided into ...[more]

PMID: 33468527

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Dataset Information

Early Chronic Kidney Disease Care Programme delays kidney function deterioration in patients with stage I-IIIa chronic kidney disease: an observational cohort study in Taiwan.

Objectives

Design

Setting

Participants

Outcome measures

Results

Conclusions

Publications

Early Chronic Kidney Disease Care Programme delays kidney function deterioration in patients with stage I-IIIa chronic kidney disease: an observational cohort study in Taiwan.

Similar Datasets

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