Ontology highlight
ABSTRACT:
SUBMITTER: I KY
PROVIDER: S-EPMC7820815 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
I Kuan-Yu KY Tseng Wen-Yi WY Wang Wen-Chih WC Gordon Siamon S Ng Kwai-Fong KF Lin Hsi-Hsien HH
Frontiers in immunology 20210108
EMR2/ADGRE2 is an adhesion G protein-coupled receptor differentially expressed by human myeloid cells. It modulates diverse cellular functions of innate immune cells and a missense EMR2 variant is directly responsible for vibratory urticaria. Recently, EMR2 was found to activate NLRP3 inflammasome in monocytes <i>via</i> interaction with FHR1, a regulatory protein of complement Factor H. However, the functional involvement of EMR2 activation and its signaling mechanisms in eliciting NLRP3 inflam ...[more]