Ontology highlight
ABSTRACT:
SUBMITTER: Bhudia N
PROVIDER: S-EPMC6976652 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Bhudia Nisha N Desai Sapna S King Natalie N Ancellin Nicolas N Grillot Didier D Barnes Ashley A AA Dowell Simon J SJ
Scientific reports 20200122 1
The experimental evidence that Adhesion G Protein-Coupled Receptors (aGPCRs) functionally couple to heterotrimeric G proteins has been emerging in incremental steps, but attributing biological significance to their G protein signalling function still presents a major challenge. Here, utilising activated truncated forms of the receptors, we show that ADGRE2/EMR2 and ADGRE5/CD97 are G protein-coupled in a variety of recombinant systems. In a yeast-based assay, where heterologous GPCRs are coupled ...[more]