Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC7821301 | biostudies-literature | 2021 Mar
REPOSITORIES: biostudies-literature
Zhang Xiaoming X Heng Yang Y Kooistra Susanne M SM van Weering Hilmar R J HRJ Brummer Maaike L ML Gerrits Emma E Wesseling Evelyn M EM Brouwer Nieske N Nijboer Tjalling W TW Dubbelaar Marissa L ML Boddeke Erik W G M EWGM Eggen Bart J L BJL
Glia 20201017 3
The DNA excision repair protein Ercc1 is important for nucleotide excision, double strand DNA break, and interstrand DNA crosslink repair. In constitutive Ercc1-knockout mice, microglia display increased phagocytosis, proliferation and an enhanced responsiveness to lipopolysaccharide (LPS)-induced peripheral inflammation. However, the intrinsic effects of Ercc1-deficiency on microglia are unclear. In this study, Ercc1 was specifically deleted from Cx3cr1-expressing cells and changes in microglia ...[more]