Ontology highlight
ABSTRACT:
SUBMITTER: Schwenkgrub J
PROVIDER: S-EPMC7821901 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Schwenkgrub Joanna J Harrell Evan R ER Bathellier Brice B Bouvier Julien J
Science advances 20201204 49
V2a neurons are a genetically defined cell class that forms a major excitatory descending pathway from the brainstem reticular formation to the spinal cord. Their activation has been linked to the termination of locomotor activity based on broad optogenetic manipulations. However, because of the difficulties involved in accessing brainstem structures for in vivo cell type-specific recordings, V2a neuron function has never been directly observed during natural behaviors. Here, we imaged the activ ...[more]