Ontology highlight
ABSTRACT:
SUBMITTER: Flesher JL
PROVIDER: S-EPMC7822220 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Flesher Jessica L JL Paterson-Coleman Elyse K EK Vasudeva Priya P Ruiz-Vega Rolando R Marshall Michaela M Pearlman Eric E MacGregor Grant R GR Neumann Jonathan J Ganesan Anand K AK
Pigment cell & melanoma research 20191016 2
MITF, a gene that is mutated in familial melanoma and Waardenburg syndrome, encodes multiple isoforms expressed from alternative promoters that share common coding exons but have unique amino termini. It is not completely understood how these isoforms influence pigmentation in different tissues and how the expression of these independent isoforms of MITF is regulated. Here, we show that melanocytes express two isoforms of MITF, MITF-A and MITF-M. The expression of MITF-A is partially regulated b ...[more]