Dataset Information

Individual differences in rat sensitivity to CO2.

ABSTRACT: Feelings of fear, anxiety, dyspnea and panic when inhaling carbon dioxide (CO2) are variable among humans, in part due to differences in CO2 sensitivity. Rat aversion to CO2 consistently varies between individuals; this variation in aversion may reflect CO2 sensitivity, but other personality traits could also account for individual differences in aversion. The aims of this study were to 1) assess the stability of individual differences in rat aversion to CO2, 2) determine if individual differences in sweet reward motivation are associated with variation in aversion to CO2, and 3) assess whether variation in aversion to CO2 is related to individual differences in motivation to approach gains (promotion focus) or maintain safety (prevention focus). Twelve female Sprague Dawley rats were exposed multiple times at three different ages (3, 9 and 16 months old) to CO2 in approach-avoidance testing to assess motivation to avoid CO2 against motivation to gain sweet rewards. Rats were also tested for motivation to find hidden sweet rewards, and for their motivation to approach rewards or darkness. Tolerance to CO2 increased with repeated exposures and was higher at older ages. Individual differences in aversion to CO2 were highly repeatable but unrelated to motivation for sweet rewards or the strength of promotion and prevention focus. These results indicate that individual differences in aversion to CO2 reflect variation in CO2 sensitivity.

SUBMITTER: Amendola L

PROVIDER: S-EPMC7822239 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Individual differences in rat sensitivity to CO2.

Améndola Lucía L Ratuski Anna A Weary Daniel M DM

PloS one 20210122 1

Feelings of fear, anxiety, dyspnea and panic when inhaling carbon dioxide (CO2) are variable among humans, in part due to differences in CO2 sensitivity. Rat aversion to CO2 consistently varies between individuals; this variation in aversion may reflect CO2 sensitivity, but other personality traits could also account for individual differences in aversion. The aims of this study were to 1) assess the stability of individual differences in rat aversion to CO2, 2) determine if individual differenc ...[more]

PMID: 33481851

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Project description:The derivation of scalar implicatures for the quantifier some has been widely studied to investigate the computation of pragmatically enriched meanings. For example, the sentence "I found some books" carries the semantic interpretation that at least one book was found, but its interpretation is often enriched to include the implicature that not all the books were found. The implicature is argued to be more likely to arise when it is relevant for addressing a question under discussion (QUD) in the context, e.g., when "I found some books" is uttered in response to "Did you find all the books?" as opposed to "Did you find any books?". However, most experimental studies have not examined the influence of context on some, instead testing some sentences in isolation. Moreover, no study to our knowledge has examined individual differences in the ability to utilize context in interpreting some, whereas individual variation in deriving implicatures for some sentences in isolation is widely attested, with alternative proposals attributing this variation to individual differences in cognitive resources (e.g., working memory) or personality-based pragmatic abilities (e.g., as assessed by the Autism-Spectrum Quotient). The current study examined how context influences the interpretation of some in a story-sentence matching task, where participants rated some statements ("I cut some steaks") uttered by one character, in response to another character's question (QUD) that established the implicature as relevant ("Did you cut all the steaks?") or irrelevant ("Did you cut any steaks?"). We also examined to what extent individuals' sensitivity to QUD is modulated by individual differences via a battery of measures assessing cognitive resources, personality-based pragmatic abilities, and language abilities (which have been argued to modulate comprehension in other domains). Our results demonstrate that QUD affects the interpretation of some, and reveal that individual differences in sensitivity to QUD are modulated by both cognitive resources and personality-based pragmatic abilities. While previous studies have argued alternatively for cognitive resources or personality-based pragmatic abilities as important for deriving implicatures for some in isolation, we argue that arriving at a context-sensitive interpretation for some depends on both cognitive and personality-based properties of the individual.

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Individual differences in rat sensitivity to CO2.

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Individual differences in rat sensitivity to CO2.

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