Ontology highlight
ABSTRACT:
SUBMITTER: Ghoroghi S
PROVIDER: S-EPMC7822591 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
eLife 20210106
Cancer extracellular vesicles (EVs) shuttle at distance and fertilize pre-metastatic niches facilitating subsequent seeding by tumor cells. However, the link between EV secretion mechanisms and their capacity to form pre-metastatic niches remains obscure. Using mouse models, we show that GTPases of the Ral family control, through the phospholipase D1, multi-vesicular bodies homeostasis and tune the biogenesis and secretion of pro-metastatic EVs. Importantly, EVs from RalA or RalB depleted cells ...[more]