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Roles of Bile-Derived Exosomes in Hepatobiliary Disease.

ABSTRACT: Exosomes are vesicles with a diameter of 30-150?nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exosomal noncoding RNAs, in physiological and disease states and discussing their potential clinical applications.

SUBMITTER: Yao Y

PROVIDER: S-EPMC7822672 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Roles of Bile-Derived Exosomes in Hepatobiliary Disease.

Yao Yuan Y Jiao Dechao D Li Zhaonan Z Zhou Xueliang X Li Jing J Liu Zaoqu Z Han Xinwei X

BioMed research international 20210113

Exosomes are vesicles with a diameter of 30-150 nm produced by living cells and secreted into the extracellular matrix. Exosomes mediate cellular communication by carrying active molecules, such as nucleic acids, proteins, and liposomes. Although exosomes are found in various body fluids, little is known about bile-derived exosomes. This review is the first to summarize the methods of bile storage and isolation of biliary exosomes, highlighting the roles of bile-derived exosomes, especially exos ...[more]

PMID: 33511212

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