Ontology highlight
ABSTRACT:
SUBMITTER: Hermann A
PROVIDER: S-EPMC7822818 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Hermann Anke A Wu Guangming G Nedvetsky Pavel I PI Brücher Viktoria C VC Egbring Charlotte C Bonse Jakob J Höffken Verena V Wennmann Dirk Oliver DO Marks Matthias M Krahn Michael P MP Schöler Hans H Heiduschka Peter P Pavenstädt Hermann H Kremerskothen Joachim J
Cell death & disease 20210122 1
The WW-and-C2-domain-containing (WWC) protein family is involved in the regulation of cell differentiation, cell proliferation, and organ growth control. As upstream components of the Hippo signaling pathway, WWC proteins activate the Large tumor suppressor (LATS) kinase that in turn phosphorylates Yes-associated protein (YAP) and its paralog Transcriptional coactivator-with-PDZ-binding motif (TAZ) preventing their nuclear import and transcriptional activity. Inhibition of WWC expression leads t ...[more]