The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer.
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ABSTRACT:
SUBMITTER: Lage-Vickers S
PROVIDER: S-EPMC7822895 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
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The expression of YWHAZ and NDRG1 predicts aggressive outcome in human prostate cancer.
Lage-Vickers Sofia S Bizzotto Juan J Valacco Maria Pia MP Sanchis Pablo P Nemirovsky Sergio S Labanca Estefania E Scorticati Carlos C Mazza Osvaldo O Mitrofanova Antonina A Navone Nora N Vazquez Elba E Cotignola Javier J Gueron Geraldine G
Communications biology 20210122 1
Some prostate cancers (PCas) are histo-pathologically grouped within the same Gleason Grade (GG), but can differ significantly in outcome. Herein, we aimed at identifying molecular biomarkers that could improve risk prediction in PCa. LC ESI-MS/MS was performed on human PCa and benign prostatic hyperplasia (BPH) tissues and peptide data was integrated with omic analyses. We identified high YWHAZ and NDRG1 expression to be associated with poor PCa prognosis considering all Gleason scores (GS). YW ...[more]
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