Ontology highlight
ABSTRACT:
SUBMITTER: Monaco DR
PROVIDER: S-EPMC7822912 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Monaco Daniel R DR Sie Brandon M BM Nirschl Thomas R TR Knight Audrey C AC Sampson Hugh A HA Nowak-Wegrzyn Anna A Wood Robert A RA Hamilton Robert G RG Frischmeyer-Guerrerio Pamela A PA Larman H Benjamin HB
Nature communications 20210122 1
Allergic reactions occur when IgE molecules become crosslinked by antigens such as food proteins. Here we create the 'AllerScan' programmable phage display system to characterize the binding specificities of anti-allergen IgG and IgE antibodies in serum against thousands of allergenic proteins from hundreds of organisms at peptide resolution. Using AllerScan, we identify robust anti-wheat IgE reactivities in wheat allergic individuals but not in wheat-sensitized individuals. Meanwhile, a key whe ...[more]