Ontology highlight
ABSTRACT:
SUBMITTER: Yam-Puc JC
PROVIDER: S-EPMC7822941 | biostudies-literature | 2021 Feb
REPOSITORIES: biostudies-literature
Yam-Puc Juan Carlos JC Zhang Lingling L Maqueda-Alfaro Raul A RA Garcia-Ibanez Laura L Zhang Yang Y Davies Jessica J Senis Yotis A YA Snaith Michael M Toellner Kai-Michael KM
iScience 20210107 2
It is still not clear how B cell receptor (BCR) signaling intensity affects plasma cell (PC) and germinal center (GC) B cell differentiation. We generated Cγ1 <sup><i>Cre/wt</i></sup> Ptpn6 <sup><i>fl/fl</i></sup> mice where SHP-1, a negative regulator of BCR signaling, is deleted rapidly after B cell activation. Although immunization with T-dependent antigens increased BCR signaling, it led to PC reduction and increased apoptosis. Dependent on the antigen, the early GC B cell response was equal ...[more]