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Aging attenuates the ovarian circadian rhythm.

ABSTRACT:

Objective

To study the effect of aging on ovarian circadian rhythm.

Design

Human and animal study.

Setting

University hospital and research laboratory.

Patients/animals

Human granulosa cells were obtained by follicular aspiration from women undergoing in vitro fertilization (IVF), and ovarian and liver tissues were obtained from female C57BL/6 mice.

Intervention(s)

None.

Main outcome measure(s)

Expression of circadian genes in young and older human granulosa cells and circadian rhythm in ovaries and livers of young and older mice.

Result(s)

All examined circadian clock genes in human granulosa cells showed a downward trend in expression with aging, and their mRNA expression levels were negatively correlated with age (P?Conclusion(s)Lower ovarian reserve in older women is partially due to ovarian circadian dysrhythmia as a result of aging.

SUBMITTER: Jiang Z

PROVIDER: S-EPMC7822988 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Publications

Aging attenuates the ovarian circadian rhythm.

Jiang Ziru Z Zou Kexin K Liu Xia X Gu Hangchao H Meng Yicong Y Lin Jing J Shi Weihui W Yu Chuanjin C Jin Li L Wang Li L Liu Xinmei X Sheng Jianzhong J Huang Hefeng H Ding Guolian G

Journal of assisted reproduction and genetics 20200914 1

<h4>Objective</h4>To study the effect of aging on ovarian circadian rhythm.<h4>Design</h4>Human and animal study.<h4>Setting</h4>University hospital and research laboratory.<h4>Patients/animals</h4>Human granulosa cells were obtained by follicular aspiration from women undergoing in vitro fertilization (IVF), and ovarian and liver tissues were obtained from female C57BL/6 mice.<h4>Intervention(s)</h4>None.<h4>Main outcome measure(s)</h4>Expression of circadian genes in young and older human gran ...[more]

PMID: 32926298

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