Old macrophages lose their (circadian) rhythm.
Ontology highlight
ABSTRACT:
SUBMITTER: McRae HM
PROVIDER: S-EPMC9678643 | biostudies-literature | 2022 Apr
REPOSITORIES: biostudies-literature
Publications
Old macrophages lose their (circadian) rhythm.
McRae Helen M HM Hargreaves Diana C DC
Trends in immunology 20220310 4
Blacher and colleagues have discovered that the circadian patterns of macrophage gene expression and immune function that exist in young mice are disrupted in aging mice. KLF4 was identified as a key transcription factor (TF) regulating rhythmic expression of immune genes, which is lost in old macrophages. ...[more]
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