Ontology highlight
ABSTRACT:
SUBMITTER: Jurczak P
PROVIDER: S-EPMC7824358 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Jurczak Przemyslaw P Sikorska Emilia E Czaplewska Paulina P Rodziewicz-Motowidlo Sylwia S Zhukov Igor I Szymanska Aneta A
Membranes 20201224 1
Human cystatin C (<i>h</i>CC), a member of the superfamily of papain-like cysteine protease inhibitors, is the most widespread cystatin in human body fluids. Physiologically active <i>h</i>CC is a monomer, which dimerization and oligomerization lead to the formation of the inactive, insoluble amyloid form of the protein, strictly associated with cerebral amyloid angiopathy, a severe state causing death among young patients. It is known, that biological membranes may accelerate the oligomerizatio ...[more]