Ontology highlight
ABSTRACT:
SUBMITTER: Klimenko A
PROVIDER: S-EPMC7824513 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Klimenko Antonina A Huber Robin R Marcourt Laurence L Chardonnens Estelle E Koval Alexey A Khotimchenko Yuri S YS Ferreira Queiroz Emerson E Wolfender Jean-Luc JL Katanaev Vladimir L VL
Marine drugs 20201229 1
Triple-negative breast cancer (TNBC) represents the deadliest form of gynecological tumors currently lacking targeted therapies. The ethanol extract of the North Pacific brittle star <i>Ophiura sarsii</i> presented promising anti-TNBC activities. After elimination of the inert material, the active extract was submitted to a bioguided isolation approach using high-resolution semipreparative HPLC-UV, resulting in one-step isolation of an unusual porphyrin derivative possessing strong cytotoxic act ...[more]