Dataset Information

STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case-Control Study.

ABSTRACT:

Introduction

Phosphorylation of signal transducer and activator of transcription 6 (STAT6) in the colonic epithelium is elevated in ulcerative colitis (UC) patients, and its inhibition prevents IL-13-associated apoptosis and barrier disruption. Recently, the STAT6 rs324015 polymorphism was reported to be related to genetic susceptibility to UC.

Methods

We examined STAT6 rs324015 using the PCR-RFLP method in 268 UC cases and 357 controls. STAT6 expression was determined by quantitative reverse-transcription PCR. The gene-environment interactions were addressed by cross-over analysis.

Results

We found that the STAT6 rs324015 polymorphism enhanced the risk of UC under the homozygous, dominant, and allelic models. Further subgroup analyses indicated that this relationship was more evident in alcohol users, smokers, and those younger than 40 years. Cross-over analysis showed strong interactions of STAT6 rs324015 with smoking/alcohol use. In addition, this polymorphism was associated with the severity, and location of UC. The GG genotype was significantly associated with increased STAT6 gene levels.

Conclusion

In summary, the STAT6 rs324015 polymorphism is related with predisposition to UC in a Chinese Han population.

SUBMITTER: Dai L

PROVIDER: S-EPMC7826160 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Publications

<i>STAT6</i> rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case-Control Study.

Dai Lingying L Zhang Dan D Qian Yunzhi Y Wan Yemin Y Chang Shuchen S Qian Haihua H

Pharmacogenomics and personalized medicine 20210119

<h4>Introduction</h4>Phosphorylation of signal transducer and activator of transcription 6 (STAT6) in the colonic epithelium is elevated in ulcerative colitis (UC) patients, and its inhibition prevents IL-13-associated apoptosis and barrier disruption. Recently, the <i>STAT6</i> rs324015 polymorphism was reported to be related to genetic susceptibility to UC.<h4>Methods</h4>We examined <i>STAT6</i> rs324015 using the PCR-RFLP method in 268 UC cases and 357 controls. <i>STAT6</i> expression was d ...[more]

PMID: 33500651

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