Genomics

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WTCCC2 case-control study for Ulcerative Colitis

ABSTRACT: WTCCC2 project genome-wide case-control association study for Ulcerative Colitis (UC) using the 1958 British Birth Cohort and the UK National Blood Service collections as controls.

PROVIDER: EGAS00000000084 | EGA |

REPOSITORIES: EGA

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Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.

Barrett Jeffrey C JC   Lee James C JC   Lees Charles W CW   Prescott Natalie J NJ   Anderson Carl A CA   Phillips Anne A   Wesley Emma E   Parnell Kirstie K   Zhang Hu H   Drummond Hazel H   Nimmo Elaine R ER   Massey Dunecan D   Blaszczyk Kasia K   Elliott Timothy T   Cotterill Lynn L   Dallal Helen H   Lobo Alan J AJ   Mowat Craig C   Sanderson Jeremy D JD   Jewell Derek P DP   Newman William G WG   Edwards Cathryn C   Ahmad Tariq T   Mansfield John C JC   Satsangi Jack J   Parkes Miles M   Mathew Christopher G CG   Donnelly Peter P   Peltonen Leena L   Blackwell Jenefer M JM   Bramon Elvira E   Brown Matthew A MA   Casas Juan P JP   Corvin Aiden A   Craddock Nicholas N   Deloukas Panos P   Duncanson Audrey A   Jankowski Janusz J   Markus Hugh S HS   Mathew Christopher G CG   McCarthy Mark I MI   Palmer Colin N A CN   Plomin Robert R   Rautanen Anna A   Sawcer Stephen J SJ   Samani Nilesh N   Trembath Richard C RC   Viswanathan Anath C AC   Wood Nicholas N   Spencer Chris C A CC   Barrett Jeffrey C JC   Bellenguez Céline C   Davison Daniel D   Freeman Colin C   Strange Amy A   Donnelly Peter P   Langford Cordelia C   Hunt Sarah E SE   Edkins Sarah S   Gwilliam Rhian R   Blackburn Hannah H   Bumpstead Suzannah J SJ   Dronov Serge S   Gillman Matthew M   Gray Emma E   Hammond Naomi N   Jayakumar Alagurevathi A   McCann Owen T OT   Liddle Jennifer J   Perez Marc L ML   Potter Simon C SC   Ravindrarajah Radhi R   Ricketts Michelle M   Waller Matthew M   Weston Paul P   Widaa Sara S   Whittaker Pamela P   Deloukas Panos P   Peltonen Leena L   Mathew Christopher G CG   Blackwell Jenefer M JM   Brown Matthew A MA   Corvin Aiden A   McCarthy Mark I MI   Spencer Chris C A CC   Attwood Antony P AP   Stephens Jonathan J   Sambrook Jennifer J   Ouwehand Willem H WH   McArdle Wendy L WL   Ring Susan M SM   Strachan David P DP  

Nature genetics 20091115 12

Ulcerative colitis is a common form of inflammatory bowel disease with a complex etiology. As part of the Wellcome Trust Case Control Consortium 2, we performed a genome-wide association scan for ulcerative colitis in 2,361 cases and 5,417 controls. Loci showing evidence of association at P < 1 x 10(-5) were followed up by genotyping in an independent set of 2,321 cases and 4,818 controls. We find genome-wide significant evidence of association at three new loci, each containing at least one bio  ...[more]

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