Ontology highlight
ABSTRACT:
SUBMITTER: Kearney KJ
PROVIDER: S-EPMC7826336 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Kearney Katherine J KJ Butler Juliet J Posada Olga M OM Wilson Clare C Heal Samantha S Ali Majid M Hardy Lewis L Ahnström Josefin J Gailani David D Foster Richard R Hethershaw Emma E Longstaff Colin C Philippou Helen H
Proceedings of the National Academy of Sciences of the United States of America 20210101 3
Kallikrein (PKa), generated by activation of its precursor prekallikrein (PK), plays a role in the contact activation phase of coagulation and functions in the kallikrein-kinin system to generate bradykinin. The general dogma has been that the contribution of PKa to the coagulation cascade is dependent on its action on FXII. Recently this dogma has been challenged by studies in human plasma showing thrombin generation due to PKa activity on FIX and also by murine studies showing formation of FIX ...[more]