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New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689.

ABSTRACT: Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective activities of some of the isolated compounds were examined and structure-activity relationships were pointed out. New deoxyisoaustamides 4-6 at concentration of 1 µM revealed a statistical increase of PQ(paraquat)-treated Neuro-2a cell viability by 30-39%.

SUBMITTER: Zhuravleva OI

PROVIDER: S-EPMC7826743 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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New Deoxyisoaustamide Derivatives from the Coral-Derived Fungus Penicillium dimorphosporum KMM 4689.

Zhuravleva Olesya I OI Antonov Alexandr S AS Trang Vo Thi Dieu VTD Pivkin Mikhail V MV Khudyakova Yuliya V YV Denisenko Vladimir A VA Popov Roman S RS Kim Natalya Y NY Yurchenko Ekaterina A EA Gerasimenko Andrey V AV Udovenko Anatoly A AA Amsberg Gunhild von GV Dyshlovoy Sergey A SA Afiyatullov Shamil S SS

Marine drugs 20210112 1

Seven new deoxyisoaustamide derivatives (1-7) together with known compounds (8-10) were isolated from the coral-derived fungus Penicillium dimorphosporum KMM 4689. Their structures were established using spectroscopic methods, X-ray diffraction analysis and by comparison with related known compounds. The absolute configurations of some alkaloids were determined based on CD and NOESY data as well as biogenetic considerations. The cytotoxic and neuroprotective ac ...[more]

PMID: 33445521

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