Ontology highlight
ABSTRACT:
SUBMITTER: Nemeth AG
PROVIDER: S-EPMC7827778 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20210108 2
We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the conven ...[more]