Ontology highlight
ABSTRACT:
SUBMITTER: Samatova E
PROVIDER: S-EPMC7829197 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Samatova Ekaterina E Daberger Jan J Liutkute Marija M Rodnina Marina V MV
Frontiers in microbiology 20210111
Protein homeostasis of bacterial cells is maintained by coordinated processes of protein production, folding, and degradation. Translational efficiency of a given mRNA depends on how often the ribosomes initiate synthesis of a new polypeptide and how quickly they read the coding sequence to produce a full-length protein. The pace of ribosomes along the mRNA is not uniform: periods of rapid synthesis are separated by pauses. Here, we summarize recent evidence on how ribosome pausing affects trans ...[more]