Ontology highlight
ABSTRACT:
SUBMITTER: Darnell AM
PROVIDER: S-EPMC6516488 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Molecular cell 20180701 2
Limitation for amino acids is thought to regulate translation in mammalian cells primarily by signaling through the kinases mTORC1 and GCN2. We find that a selective loss of arginine tRNA charging during limitation for arginine regulates translation through ribosome pausing at two of six arginine codons. Surprisingly, limitation for leucine, an essential and abundant amino acid in protein, results in little or no ribosome pausing. Chemical and genetic perturbation of mTORC1 and GCN2 signaling re ...[more]