Ontology highlight
ABSTRACT:
SUBMITTER: Pellegrino R
PROVIDER: S-EPMC7829828 | biostudies-literature | 2021 Jan
REPOSITORIES: biostudies-literature
Pellegrino Rossella R Thavamani Abhishek A Calvisi Diego F DF Budczies Jan J Neumann Ariane A Geffers Robert R Kroemer Jasmin J Greule Damaris D Schirmacher Peter P Nordheim Alfred A Longerich Thomas T
Cancers 20210108 2
Different molecular mechanisms support the overexpression of the mouse double minute homolog 4 (MDM4), a functional p53 inhibitor, in human hepatocellular carcinoma (HCC). However, the transcription factors (TFs) leading to its transcriptional upregulation remain unknown. Following promoter and gene expression analyses, putative TFs were investigated using gene-specific siRNAs, cDNAs, luciferase reporter assays, chromatin immunoprecipitation, and XI-011 drug treatment in vitro. Additionally, MDM ...[more]