Unknown

Dataset Information

0

Endogenous Retroviruses in Nervous System Disorders.

ABSTRACT: Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies.

SUBMITTER: Groger V 

PROVIDER: S-EPMC7829834 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

Endogenous Retroviruses in Nervous System Disorders.

Gröger Victoria V   Emmer Alexander A   Staege Martin S MS   Cynis Holger H  

Pharmaceuticals (Basel, Switzerland) 20210116 1

Human endogenous retroviruses (HERV) have been implicated in the pathogenesis of several nervous system disorders including multiple sclerosis and amyotrophic lateral sclerosis. The toxicity of HERV-derived RNAs and proteins for neuronal cells has been demonstrated. The involvement of HERV in the pathogenesis of currently incurable diseases might offer new treatment strategies based on the inhibition of HERV activities by small molecules or therapeutic antibodies. ...[more]

Similar Datasets

Unknown Demystified. Human endogenous retroviruses.
| S-EPMC1187282 | biostudies-literature
Unknown C1q and central nervous system disorders.
| S-EPMC10076750 | biostudies-literature
Unknown Targeting protein kinases in central nervous system disorders.
| S-EPMC2825114 | biostudies-literature
Unknown Oligonucleotide therapies for disorders of the nervous system.
| S-EPMC6043900 | biostudies-literature
Unknown Distribution of endogenous retroviruses in crocodilians.
| S-EPMC2748012 | biostudies-literature
Unknown Human Endogenous Retroviruses in Glioblastoma Multiforme.
| S-EPMC8067472 | biostudies-literature
Unknown HERVd: database of human endogenous retroviruses.
| S-EPMC99133 | biostudies-literature
Unknown Characterization of endogenous retroviruses in sheep.
| S-EPMC224999 | biostudies-literature
Unknown Endogenous retroviruses are dysregulated in ALS.
| S-EPMC11233923 | biostudies-literature
Unknown Human Endogenous Retroviruses in Neurological Diseases.
| S-EPMC7185488 | biostudies-literature