Concussion increases CA1 activity during prolonged inactivity in a familiar environment.
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ABSTRACT:
SUBMITTER: Tummala SR
PROVIDER: S-EPMC7830810 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
Concussion increases CA1 activity during prolonged inactivity in a familiar environment.
Tummala Shanti R SR Hemphill Matthew A MA Nam Andrea A Meaney David F DF
Experimental neurology 20200817
Although hippocampal damage plays a key role in impairments after concussion, differences in hippocampal information processing during recovery are unknown. Micro-endoscopic calcium imaging was performed before and after primary blast injury in freely behaving mice in two environments: their familiar home cage and a novel open field. Results show that after concussion CA1 activity increased in the familiar environment in which animals were awake and mostly immobile but was unaltered in a novel e ...[more]
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