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Replicative capacity of four porcine enteric coronaviruses in LLC-PK1 cells.

ABSTRACT: Enteric coronaviruses (CoVs) are major pathogens that cause diarrhea in piglets. To date, four porcine enteric CoVs have been identified: transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and HKU2-like porcine enteric alphacoronavirus (PEAV). In this study, we investigated the replicative capacity of these four enteric CoVs in LLC-PK1 cells, a porcine kidney cell line. The results showed that LLC-PK1 cells are susceptible to all four enteric CoVs, particularly to TGEV and PDCoV infections, indicating that LLC-PK1 cells can be applied to porcine enteric CoV research in vitro, particularly for coinfection studies.

SUBMITTER: Xiao W

PROVIDER: S-EPMC7831621 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature

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Replicative capacity of four porcine enteric coronaviruses in LLC-PK1 cells.

Xiao Wenwen W Wang Xunlei X Wang Jing J Fang Puxian P Xiao Shaobo S Fang Liurong L

Archives of virology 20210125 3

Enteric coronaviruses (CoVs) are major pathogens that cause diarrhea in piglets. To date, four porcine enteric CoVs have been identified: transmissible gastroenteritis virus (TGEV), porcine epidemic diarrhea virus (PEDV), porcine deltacoronavirus (PDCoV), and HKU2-like porcine enteric alphacoronavirus (PEAV). In this study, we investigated the replicative capacity of these four enteric CoVs in LLC-PK1 cells, a porcine kidney cell line. The results showed that LLC-PK1 cells are susceptible to all ...[more]

PMID: 33492525

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