Expression data from ATRA-treated LLC-PK1 cells

ABSTRACT: We have established a role for p-ERK in mediating ATRA cytoprotection against chemical-induced injury to LLC-PK1 renal proximal tubule epithelial cells. The present studies were conducted to assess downstream signaling from p-ERK in ATRA-mediated cytoprotection. Gene expression profiling via microarray and ontology analyses indicated an upregulation of genes associated with cell proliferation and differentiation shortly after (0.5 and 1 hr) ATRA (25 μM) treatment. Target genes of these transcription factors associated with ribosome biogenesis, DNA replication, DNA repair, and the cell cycle were significantly increased by 4 hr.

ORGANISM(S): Sus scrofa

PROVIDER: GSE110832 | GEO | 2020/03/01

REPOSITORIES: GEO